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首页> 外文OA文献 >Effect of pentobarbital anesthesia on amikacin concentrations in plasma and perilymph and evaluation of multiple sampling in perilymph of guinea pigs.
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Effect of pentobarbital anesthesia on amikacin concentrations in plasma and perilymph and evaluation of multiple sampling in perilymph of guinea pigs.

机译：戊巴比妥麻醉对豚鼠血浆和周围淋巴中丁胺卡那霉素浓度的影响以及多次采样在外周淋巴中的评估。

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The purpose of this study was to determine whether a multiple-sampling procedure could be used in guinea pigs to study the kinetics of amikacin in perilymph. Amikacin was infused intravenously for 6 h into conscious anesthetized guinea pigs, and the concentrations of the drug in plasma and perilymph were measured. From each anesthetized guinea pig, five to six perilymph samples were collected from one ear, and one sample was collected from the other ear at 6 h. The concentrations of amikacin in perilymph were dose proportional and increased slowly during the 6-h infusion. However, after 6 h of intravenous infusion, the concentrations of amikacin in perilymph of the multiply sampled ears were significantly higher than those of the singly sampled ears, indicating that the multiple-sampling procedure should not be used as is to study the kinetics of amikacin in perilymph. Amikacin concentrations in perilymph were linearly related to amikacin concentrations in plasma in pentobarbital-anesthetized animals, as had previously been observed for conscious guinea pigs. However, the slope of the regression line was only 0.09 for anesthetized animals compared with 0.24 for conscious animals. Drug concentrations in plasma were found to be threefold higher in anesthetized animals, whereas drug levels in perilymph were the same in both groups at similar dosing rates. These results indicate that the amikacin concentration in perilymph is not solely dependent upon its concentration in plasma and that other factor(s) can affect the entry of amikacin into the inner ear.
机译：这项研究的目的是确定是否可以在豚鼠中使用多重采样程序来研究阿米卡星在淋巴中的动力学。将阿米卡星静脉注射到清醒麻醉的豚鼠中6小时，并测量血浆和外周淋巴中药物的浓度。从每只麻醉的豚鼠中，在6h时从一只耳朵中收集5至6个淋巴液样本，并从另一只耳朵中收集一个样品。周淋巴中丁胺卡那霉素的浓度与剂量成正比，并在6小时输注期间缓慢增加。但是，静脉输注6小时后，多次取样的耳朵的淋巴中阿米卡星的浓度显着高于单次取样的耳朵，这表明不应直接使用多重取样方法来研究阿米卡星的动力学在旁淋巴中。如先前在有意识的豚鼠中所观察到的那样，戊巴比妥麻醉动物的外周淋巴中阿米卡星浓度与血浆中阿米卡星浓度呈线性关系。但是，麻醉动物的回归线斜率仅为0.09，而有意识的动物为0.24。发现在麻醉的动物中血浆药物浓度高出三倍，而两组在外周血中的药物水平在相同的给药速率下是相同的。这些结果表明，外周淋巴中的丁胺卡那霉素浓度不仅仅取决于其血浆中的浓度，其他因素也可能影响丁胺卡那霉素进入内耳。

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